Chromatin, made by DNA and histone proteins, contains the genetic information required for life. Covalent and dynamic modifications of histones modulate the structure of chromatin and influence gene expression. In this study, we will use a simple model organism, the round worm C. elegans, in which histone modifications and regulation are very similar to humans. We will focus on the methylation of Lysine 4 of Histone 3 (H3K4me), a modification often perturbed in pathological conditions, such as in cancer (e.g. leukemia) and nerve system disorders (e.g. autism). We will analyze the relevance of H3K4 methylation in transcription of genes and in the regulation of development. Our study will contribute to clarify the impact of H3K4 methylation and provide important information to understand its role in diseases.
